Publications
Selected highlights from our work, followed by our latest papers from PubMed.
Featured work
Cell Communication and Signaling
Cholesteryl esters and high protein-to-lipid ratios distinguish non-vesicular extracellular particles from extracellular vesicles
Definitive biochemical framework—relying on distinct cholesteryl ester profiles and high protein-to-lipid ratios—to robustly distinguish newly recognized non-vesicular particles (NVEPs) from canonical extracellular vesicles.
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Cardiovascular Diabetology
Reduced circulating CD63+ extracellular vesicle levels associate with atherosclerosis in hypercholesterolaemic mice and humans
Circulating CD63+ EV levels are significantly depleted in hypercholesterolemia across both animal models and clinical patients, providing a new diagnostic lens for cardiovascular disease and reinforcing the therapeutic benefit of PCSK9 inhibitors.
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International Journal of Molecular Sciences
Exosome Biogenesis: Meta-Analysis of Intraluminal Vesicle Size Across Species
Comprehensive meta-analysis of intraluminal vesicle sizes across species revealed a conserved upper structural limit of 200 nm, closing a significant knowledge gap in the fundamental mechanisms of extracellular vesicle biogenesis
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Recent publications
Cholesteryl esters and high protein-to-lipid ratios distinguish non-vesicular extracellular particles from extracellular vesicles.
Ghosal S, Leporati R, Varga Á, Susanszki P, Fekete N, László T, et al.
Cell communication and signaling : CCS · 2026
Exosome Biogenesis: Meta-Analysis of Intraluminal Vesicle Size Across Species.
Ghosal S, Leporati R, Yilmaz B, Kestecher BM, Bodnár BR, Fattah MA, et al.
International journal of molecular sciences · 2026
Improved Accessibility of Extracellular Vesicle Surface Molecules Upon Partial Removal of the Protein Corona by High Ionic Strength.
Försönits AI, Tóth EÁ, Jezsoviczky S, Bárkai T, Khamari D, Galinsoga A, et al.
Journal of extracellular vesicles · 2025
Isolation and Characterization of Tissue-Derived Extracellular Vesicles from Mouse Lymph Nodes.
Bodnár BR, Ghosal S, Kestecher BM, Királyhidi P, Försönits A, Fekete N, et al.
International journal of molecular sciences · 2025
Therapeutic and pharmacological applications of extracellular vesicles and lipoproteins.
Németh K, Kestecher BM, Ghosal S, Bodnár BR, Kittel Á, Hambalkó S, et al.
British journal of pharmacology · 2024
Reduced circulating CD63(+) extracellular vesicle levels associate with atherosclerosis in hypercholesterolaemic mice and humans.
Kestecher BM, Németh K, Ghosal S, Sayour NV, Gergely TG, Bodnár BR, et al.
Cardiovascular diabetology · 2024
High fat diet and PCSK9 knockout modulates lipid profile of the liver and changes the expression of lipid homeostasis related genes.
Németh K, Tóth B, Sarnyai F, Koncz A, Lenzinger D, Kereszturi É, et al.
Nutrition & metabolism · 2023
Large-scale production of extracellular vesicles: Report on the "massivEVs" ISEV workshop.
Paolini L, Monguió-Tortajada M, Costa M, Antenucci F, Barilani M, Clos-Sansalvador M, et al.
Journal of extracellular biology · 2022
Engineered Cas9 extracellular vesicles as a novel gene editing tool.
Osteikoetxea X, Silva A, Lázaro-Ibáñez E, Salmond N, Shatnyeva O, Stein J, et al.
Journal of extracellular vesicles · 2022
Quantification of protein cargo loading into engineered extracellular vesicles at single-vesicle and single-molecule resolution.
Silva AM, Lázaro-Ibáñez E, Gunnarsson A, Dhande A, Daaboul G, Peacock B, et al.
Journal of extracellular vesicles · 2021
Endosomal escape enhancing compounds facilitate functional delivery of extracellular vesicle cargo.
Heath N, Osteikoetxea X, de Oliveria TM, Lázaro-Ibáñez E, Shatnyeva O, Schindler C, et al.
Nanomedicine (London, England) · 2019
Extracellular vesicles induce minimal hepatotoxicity and immunogenicity.
Saleh AF , Lázaro-Ibáñez E , Forsgard MA , Shatnyeva O , Osteikoetxea X , Karlsson F , et al.
Nanoscale · 2019
An improved 96 well plate format lipid quantification assay for standardisation of experiments with extracellular vesicles.
Visnovitz T, Osteikoetxea X, Sódar BW, Mihály J, Lőrincz P, Vukman KV, et al.
Journal of extracellular vesicles · 2019
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.
Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, et al.
Journal of extracellular vesicles · 2018
Detection and proteomic characterization of extracellular vesicles in human pancreatic juice.
Osteikoetxea X, Benke M, Rodriguez M, Pálóczi K, Sódar BW, Szvicsek Z, et al.
Biochemical and biophysical research communications · 2018
Rapid isolation and enrichment of extracellular vesicle preparations using anion exchange chromatography.
Heath N, Grant L, De Oliveira TM, Rowlinson R, Osteikoetxea X, Dekker N, et al.
Scientific reports · 2018
Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA.
Németh A, Orgovan N, Sódar BW, Osteikoetxea X, Pálóczi K, Szabó-Taylor KÉ, et al.
Scientific reports · 2017
Monocyte activation drives preservation of membrane thiols by promoting release of oxidised membrane moieties via extracellular vesicles.
Szabó-Taylor KÉ, Tóth EÁ, Balogh AM, Sódar BW, Kádár L, Pálóczi K, et al.
Free radical biology & medicine · 2017
A standardized method to determine the concentration of extracellular vesicles using tunable resistive pulse sensing.
Vogel R, Coumans FA, Maltesen RG, Böing AN, Bonnington KE, Broekman ML, et al.
Journal of extracellular vesicles · 2016
Extracellular vesicles in cardiovascular disease: are they Jedi or Sith?
Osteikoetxea X, Németh A, Sódar BW, Vukman KV, Buzás EI
The Journal of physiology · 2016